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1.
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15 p, 3.9 MB |
GSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal cancer metastases
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Sala, Rita (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rioja-Blanco, Elisa (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Serna, Naroa (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Sánchez-García, Laura (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Álamo, Patricia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Alba-Castellón, Lorena (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Casanova Rigat, Isolda (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
López Pousa, Antonio (Institut d'Investigació Biomèdica Sant Pau) ;
Unzueta Elorza, Ugutz (Institut d'Investigació Biomèdica Sant Pau) ;
Céspedes, María Virtudes (Institut d'Investigació Biomèdica Sant Pau) ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Mangues, Ramon 1957- (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Colorectal cancer (CRC) remains the third cause of cancer-related mortality in Western countries, metastases are the main cause of death. CRC treatment remains limited by systemic toxicity and chemotherapy resistance. [...]
2022 -  10.1080/10717544.2022.2069302
Drug Delivery, Vol. 29 Núm. 1 (2022) , p. 1384-1397
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21 p, 4.0 MB |
Long-term corticosteroid-induced chronic glaucoma model produced by intracameral injection of dexamethasone-loaded PLGA microspheres
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Rodrigo, MJ (Instituto de Salud Carlos III) ;
Garcia-Herranz, D (Hospital Clínico San Carlos (Madrid)) ;
Aragón-Navas, Alba (Hospital Clínico San Carlos (Madrid)) ;
Subias, M (Universidad de Zaragoza. Miguel Servet Ophthalmology Research Group) ;
Martínez-Rincón, Teresa (Universidad de Zaragoza. Miguel Servet Ophthalmology Research Group) ;
Mendez-Martínez, S (Universidad de Zaragoza. Miguel Servet Ophthalmology Research Group) ;
Cardiel, MJ (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza) ;
García-Feijoo, J (Universidad Complutense de Madrid. Departamento de Inmunología, Oftalmología y Otorrinolaringología) ;
Ruberte, Jesús (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Herrero-Vanrell, Rocío (Hospital Clínico San Carlos (Madrid)) ;
Pablo, Luis E (Universidad de Zaragoza. Miguel Servet Ophthalmology Research Group) ;
Garcia-Martin, Elena (Universidad de Zaragoza. Miguel Servet Ophthalmology Research Group) ;
Bravo-Osuna, Irene (Hospital Clínico San Carlos (Madrid))
To evaluate a new chronic glaucoma model produced by intracameral injection of dexamethasone-loaded poly lactic-co-glycolic acid microspheres (Dex-PLGA-Ms) over six months. Healthy rats received two injections (at baseline and Week 4) of Dex-PLGA-Ms into the anterior chamber of the right eye. [...]
2021 - 10.1080/10717544.2021.1998245
Drug Delivery, Vol. 28 (november 2021) , p. 2427-2446
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0 p, 3.4 MB |
Mimicking chronic glaucoma over 6 months with a single intracameral injection of dexamethasone/fibronectin-loaded PLGA microspheres
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Aragón-Navas, Alba (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Rodrigo Sanjuan, María Jesús (Instituto de Salud Carlos III) ;
Garcia-Herranz, David (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Martínez-Rincón, Teresa (Universidad de Zaragoza. Instituto de Investigación Sanitaria de Aragón) ;
Subías, Manuel (Universidad de Zaragoza. Instituto de Investigación Sanitaria de Aragón) ;
Mendez-Martínez, Silvia (Universidad de Zaragoza. Instituto de Investigación Sanitaria de Aragón) ;
Ruberte, Jesús (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Pampalona Sala, Judit (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Bravo-Osuna, Irene (Instituto de Salud Carlos III) ;
Pablo, Luis E. (Instituto de Salud Carlos III) ;
Garcia-Martin, Elena (Instituto de Salud Carlos III) ;
Herrero-Vanrell, Rocío (Instituto de Salud Carlos III)
To create a chronic glaucoma animal model by a single intracameral injection of biodegradable poly lactic-co-glycolic acid (PLGA) microspheres (Ms) co-loaded with dexamethasone and fibronectin (MsDexaFibro). [...]
2022 - 10.1080/10717544.2022.2096712
Drug Delivery, Vol. 29 (july 2022) , p. 2357-2374
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5.
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10 p, 2.4 MB |
Ion-dependent slow protein release from in vivo disintegrating micro-granules
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Álamo, Patricia (Institut d'Investigació Biomèdica Sant Pau) ;
Parladé Molist, Eloi (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
López-Laguna, Hèctor (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Voltà-Durán, Eric (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Unzueta Elorza, Ugutz (Institut d'Investigació Biomèdica Sant Pau) ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Mangues, Ramon 1957- (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Through the controlled addition of divalent cations, polyhistidine-tagged proteins can be clustered in form of chemically pure and mechanically stable micron-scale particles. Under physiological conditions, these materials act as self-disintegrating protein depots for the progressive release of the forming polypeptide, with potential applications in protein drug delivery, diagnosis, or theragnosis. [...]
2021 - 10.1080/10717544.2021.1998249
Drug Delivery, Vol. 28, Issue 1 (November 2021) , p. 2383-2391
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6.
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2.5 MB |
Graphene oxide enhances alginate encapsulated cells viability and functionality while not affecting the foreign body response
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Ciriza, Jesús (NanoBioCel Group, Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country, UPV/EHU) ;
Saenz del Burgo, Laura (NanoBioCel Group, Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country, UPV/EHU) ;
Gurruchaga, Haritz (NanoBioCel Group, Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country, UPV/EHU) ;
Borràs i Serres, Francesc Enric (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Franquesa, Marcella (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Orive, Gorka (NanoBioCel Group, Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country, UPV/EHU) ;
Hernández, Rosa Maria (NanoBioCel Group, Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country, UPV/EHU) ;
Pedraz, José Luis (NanoBioCel Group, Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country, UPV/EHU) ;
Universitat Autònoma de Barcelona
The combination of protein-coated graphene oxide (GO) and microencapsulation technology has moved a step forward in the challenge of improving long-term alginate encapsulated cell survival and sustainable therapeutic protein release, bringing closer its translation from bench to the clinic. [...]
2018 - 10.1080/10717544.2018.1474966
Drug Delivery, Vol. 25 (may 2018) , p. 1147-1160
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7.
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1.9 MB |
AKT2 siRNA delivery with amphiphilic-based polymeric micelles show efficacy against cancer stem cells
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Rafael, Diana (Universitat Autònoma de Barcelona) ;
Gener, Petra (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Andrade, Fernanda (Instituto de Salud Carlos III) ;
Seras-Franzoso, Joaquin (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montero, Sara (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fernández Caparrós, Yolanda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hidalgo, Manuel (Rosenberg Clinical Cancer Center Beth Israel Deaconess Medical Center) ;
Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Florindo, Helena F. (Universidade de Lisboa) ;
Abasolo, Ibane (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Schwartz, Simon (Instituto de Salud Carlos III) ;
Videira, Mafalda (Universidade de Lisboa) ;
Universitat Autònoma de Barcelona
Development of RNA interference-based therapies with appropriate therapeutic window remains a challenge for advanced cancers. Because cancer stem cells (CSC) are responsible of sustaining the metastatic spread of the disease to distal organs and the progressive gain of resistance of advanced cancers, new anticancer therapies should be validated specifically for this subpopulation of cells. [...]
2018 - 10.1080/10717544.2018.1461276
Drug Delivery, Vol. 25 (april 2018) , p. 961-972
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89 p, 3.5 MB |
Design strategies for shape-controlled magnetic iron oxide nanoparticles
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Gómez Roca, Alejandro (Institut Català de Nanociència i Nanotecnologia) ;
Gutiérrez, Lucía (Instituto de Nanociencia de Aragón) ;
Gavilán, Helena (Instituto de Ciencia de Materiales de Madrid) ;
Fortes Brollo, Maria Eugênia (Instituto de Ciencia de Materiales de Madrid) ;
Veintemillas Verdaguer, Sabino (Instituto de Ciencia de Materiales de Madrid) ;
Morales, María del Puerto (Instituto de Ciencia de Materiales de Madrid)
Ferrimagnetic iron oxide nanoparticles (magnetite or maghemite) have been the subject of an intense research, not only for fundamental research but also for their potentiality in a widespread number of practical applications. [...]
2019 - 10.1016/j.addr.2018.12.008
Advanced drug delivery reviews, Vol. 138 (January 2019) , p. 68-104
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11 p, 445.0 KB |
Validation of the 'Test of the Adherence to Inhalers' (TAI) for Asthma and COPD Patients
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Plaza, Vicente (Institut d'Investigació Biomèdica Sant Pau) ;
Fernández-Rodríguez, Concepción (Universidad de Oviedo) ;
Melero, Carlos (Hospital Universitario 12 de Octubre (Madrid)) ;
Cosio, Borja G.. (Institut d'Investigació Sanitària Illes Balears) ;
Entrenas, Luís Manuel (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Pérez de Llano, Luis (Hospital Universitario Lucus Augusti (Lugo)) ;
Gutiérrez-Pereyra, Fernando (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Tarragona, Eduard (Chiesi Espanya. Departament Mèdic) ;
Palomino, Rosa (GOC Networking) ;
López Viña, Antolín (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Universitat Autònoma de Barcelona
Background: To validate the 'Test of Adherence to Inhalers' (TAI), a 12-item questionnaire designed to assess the adherence to inhalers in patients with COPD or asthma. Methods: A total of 1009 patients with asthma or COPD participated in a cross-sectional multicenter study. [...]
2016 - 10.1089/jamp.2015.1212
Journal of Aerosol Medicine and Pulmonary Drug Delivery, Vol. 29 (april 2016) , p. 142-152
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